Lymphocyte antigen 75/CD205 Recombinant Rabbit mAb (S-2707-25)
SKU: 90799566200

Lymphocyte antigen 75/CD205 Recombinant Rabbit mAb (S-2707-25)

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Description

Lymphocyte antigen 75/CD205 Recombinant Rabbit mAb (S-2707-25)Product Specification Host Rabbit Antigen CD205 Synonyms Lymphocyte antigen 75; Ly 75; C type lectin domain family 13 member B; DEC 205; gp200 MR6; CLEC13B; LY75 Immunogen Recombinant Protein Location Membrane Accession O60449 Clone Number S 2707 25 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample THP 1, Daudi Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance

Product Specification


Host Rabbit
Antigen CD205
Synonyms Lymphocyte antigen 75; Ly-75; C-type lectin domain family 13 member B; DEC-205; gp200-MR6; CLEC13B; LY75
Immunogen Recombinant Protein
Location Membrane
Accession O60449
Clone Number S-2707-25
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample THP-1, Daudi
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:1000 Hu

Background

CD205, also known as DEC205 or LY75, is a ~205 kDa type I transmembrane glycoprotein belonging to the macrophage mannose receptor family of C-type lectins; it contains an N-terminal cysteine-rich domain, a fibronectin type II repeat, ten tandem C-type lectin-like carbohydrate-recognition domains, a single transmembrane segment and a short cytoplasmic tail harboring the tyrosine-based “FERN” and “DIEEV” endosomal sorting motifs that drive constitutive clathrin-mediated internalization and recycling to late endosomes/MHC class II compartments. Predominantly expressed on CD8α⁺ dendritic cells, thymic epithelial cells and certain B subsets, CD205 functions as a pattern-recognition receptor that binds apoptotic/necrotic cells, selected glycoproteins and CpG-rich nucleic acids, enabling efficient capture, processing and cross-presentation of antigens for initiation of CD8⁺ T-cell immunity; this property has made it a premier target for receptor-directed vaccination strategies in which antigens are fused to anti-CD205 antibodies to elicit potent, antigen-specific tolerance or protective responses. In addition, CD205 participates in peripheral T-cell deletion, central tolerance through negative selection in the thymus, and has been implicated in autoimmune diseases, tumor immunosurveillance and metastasis, with its expression levels correlating with prognosis in several cancers, thereby serving as both a biomarker and a therapeutic gateway in immunotherapy.

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SKU: 90799566200

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Verified Purchase
Emma
Carnegie, US
★★★★★ 5
Great Little Grinder — Solid Build & Easy to Use!
I’ve really enjoyed using this manual coffee grinder! For the price, it’s an excellent find. The adjustable settings work surprisingly well — I’ve been able to get a consistent grind whether I’m brewing for espresso or French press, which isn’t always the case with more affordable manual grinders. The ceramic burr gives a nice, even grind without overheating the beans, which helps preserve the flavor. It’s easy to use and straightforward to adjust. The grind size clicks into place firmly, so you don’t feel like it’s going to slip or change while you’re using it. One fill gives me enough coffee for about two cups, which is perfect for my morning routine or when I’m brewing a small batch. The build quality feels sturdy and durable, with a sleek look that doesn’t feel cheap. The handle turns smoothly and doesn’t wobble, which makes the whole experience feel solid and satisfying. I’ve taken it on a short weekend trip already, and it’s lightweight and compact enough for travel or camping. If you're someone who loves the ritual of grinding your own beans or just wants a reliable backup grinder for when the power’s out, I’d highly recommend this one. Great value for a tool that feels like it’ll last!
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Reviewed in the United States on June 10, 2025
K
Verified Purchase
K. DeWitt
Grantham, US
★★★★★ 5
Love it!
Perfect little manual grinder for my camp coffee! No power needed. Great value. Seems to be durable. Has different grinding settings. Easy to use. Definitely recommend!
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Reviewed in the United States on April 27, 2026
K
Verified Purchase
K. Searfos
San Leandro, US
★★★★★ 3
Seems like a decent product, but it's not for me
First off, a small caveat: this is the first manual grinder I have used. I am trying to highlight things I think might be unique to this model, but some of these might be "that's just how manual grinders work" problems. First and foremost, I can only cram about 20g of coffee into here at one time. If I'm making an 8oz cup, that tends to be enough -- but no larger than that. I also find it hard to load; last time I tried to just pour beans in most of them ended up on the floor. One scoop at a time is annoying if you are adding 20 grams of coffee, especially if you use a small scoop. Also, I personally dislike that the body that holds the unground beans is opaque. I have to turn the thing upside down to determine if I have more left in there to grind or not. This is likely the same for other models but I don't think it makes for an ideal user experience. Now, on the upside, it's compact, easy to use, and easy to clean. I don't know how to gauge the accuracy or consistency of the grind, but it seems to produce a somewhat finer grind than my electric burr grinder at what I would expect to be the same setting (20/40 on here is more fine than 14/28 on the other grinder, even though I would expect both of those to be "medium"). I'm someone who prefers slightly coarser grind, even for pour over, so this is another strike against it in my book. I have only used it two or three times due to usually making larger cups that this can accommodate, and also not enjoying spending 5 minutes rotating my arms to get the coffee ground. So I also cannot speak to durability, but the plastic and glass both seem sturdy so I do expect it to last. All in all, I love that it is lightweight, portable, and easy to clean, but I think I'm someone who prefers the ease of use that an electronic grinder can provide. And seriously, IDK how anyone is getting more than 20g of coffee into this thing at one time.
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Reviewed in the United States on January 6, 2026
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Verified Purchase
Gabriel marin
Dallas, US
★★★★★ 5
Perfect for Lattes
Size: 20 Ounces
Good for steaming 8-10 oz of milk. The nifty tool is good for scooping out your puck.
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Reviewed in the United States on February 19, 2026
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Verified Purchase
JeffTryHard
Whiting, US
★★★★★ 5
Almost blew up my microwave
Size: 20 Ounces, Size: 20 Ounces
TL;DR "A hilarious microwave mistake turned into a great home cafe upgrade. This 20oz cup is straightforward to handle, looks incredibly professional, and holds a level of heat that will literally burn you if you aren't careful." . Bought this for homemade coffee brewing, just to spice things up. But as I go ahead to heat up my new shiny stainless steel milk frother cup in the microwave, whoopdy doo. Ya can’t put stainless in the microwave! Regardless, it’s still a straightforward frother cup to handle, making it a great dollar investment for upgrading my home cafe setup. . 1. Spotless Stainless Steel: Its sleek appearance made me feel professional in the hands of an amateur like moi. Great quality! 2. Temperature Retention: I accidentally burnt myself because it stayed so hot, but that is a major positive. Proving the insulation works perfectly and keeps the milk piping hot. 3. Size: The 20oz capacity is accurate, providing the perfect amount of space for frothing without any overflow.
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Reviewed in the United States on June 6, 2026

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