IL-1 RII/CD121b Fc Chimera Protein, Human
SKU: 56831297491

IL-1 RII/CD121b Fc Chimera Protein, Human

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Description

IL-1 RII/CD121b Fc Chimera Protein, HumanProduct Specification Species Human Synonyms beta; CD121b antigen; IL 1 R beta; IL 1 RII; IL1R2; IL1RBCD121 antigen like family member B; IL 1R beta; IL1RII; IL 1RII; IL 1RT2; IL 1RT 2; interleukin 1 receptor, type II; Interleukin 1 receptor beta; MGC47725 Accession P27930 Amino Acid Sequence Phe14 Glu343 with Human IgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Endotoxin <0.

Product Specification


Species Human
Synonyms beta; CD121b antigen; IL-1 R beta; IL-1 RII; IL1R2; IL1RBCD121 antigen-like family member B; IL-1R- beta; IL1RII; IL-1RII; IL-1RT2; IL-1RT-2; interleukin 1 receptor, type II; Interleukin-1 receptor beta; MGC47725
Accession P27930
Amino Acid Sequence

Phe14-Glu343 with Human IgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)
Purity ＞95% by SDS-PAGE & SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.
Reference

1.Greenfeder, S. et al. (1995) J. Biol. Chem. 270:13757.

Background

Interleukin-1 receptor type 2 (IL1R2), also referred to as CD121 antigen-like family member B (CDw121b) or the IL-1 type II receptor, is a member of the interleukin-1 receptor family. Two specific IL-1 binding receptors have been identified: IL1RI (also known as IL1RA) and IL1RII (also known as IL1RB).
IL1R2 is a non-signaling receptor that binds to IL1A, IL1B, and IL1RN, and it plays a role in reducing the activities of IL1B. It functions as a decoy receptor by competitively binding to IL1B, thereby preventing its interaction with IL1R1. After binding to IL1B, IL1R2 modulates cellular responses through a non-signaling association with IL1RAP.
Both membrane-bound and secreted forms of IL1R2 show a preference for binding to IL1B, with less affinity for IL1A and IL1RN. The secreted form of IL1R2 has a high affinity for secreted IL1RAP, and the formation of this complex is likely a primary mechanism for the neutralization of IL1B by soluble receptors. It is hypothesized that the type II receptor, in both its membrane-bound and soluble forms, acts as a decoy for IL-1, inhibiting its action by blocking the binding of IL-1 to the signaling type I receptor complex. The recombinant IL-1 soluble receptor type II is a potent antagonist of IL-1 activity.

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SKU: 56831297491

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Product Reviews
A
Atherney Family Farm
Alexandria, US
★★★★★ 5
Nice elegant suit for any occasion.
Color: Light Blue, Size: 12, Color: Light Blue, Size: 12
The suit set is very nice, the fabric material is durable and soft. Overall stitching is tight with nice surging of the hems and great construction on the shoulders. Buttons and button wholes are well done. I'm going to iron in the creases on the front of the pants because they weren't folded properly for shipping. The material does hold on to wrinkles so don't be afraid of your iron to get a super sharp look. The color is a soft baby blue that stands out in a crowd of black suits. With the option of an elastic tie or clip on bowtie this is everything you need to make him look presentable for a variety of occasions. My only complaint about this suit kit is the dress shirt is stiff and thin. I found some loose threads that I don't trust to not get played with. I'll probably trade it out for something with a little more cotton. As far as cost goes mid range, but definitely worth the cost. I might consider something with a vest if it's a super formal event, but I'm very happy with how this suit comes together.
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Reviewed in the United States on April 18, 2026
M
Martin V.
Carnegie, US
★★★★★ 5
Modern luxury with summer fabric that performs above its price!
Color: Beige, Size: 14, Color: Beige, Size: 14
Wow! My son wore it for Easter Sunday and this suit fits the bill! The linen material is spot on--not too heavy and not too light especially since the weather is warming up now. The jacket is quality made--the design is modern executive, the stitches are strong no flaws to note. The pants are tad bit longer but that's okay, build quality is also great. The white shirt is decent and matches well with the rest of the set. The bow tie and tie itself is a great complimentary to the set, though optional to wear. The whole set just has that quality you would really look for in the price range you would want to pay. Overall, best value for for the, wear right outside the bag, maybe a light ironing otherwise it's perfect! I highly recommend it, no complaints here very happy with this suit!
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Reviewed in the United States on April 5, 2026
A
Ariel B.
Pawtucket, US
★★★★★ 4
Heavy linen character, but a beautifully tailored suit!
Color: Beige, Size: 4, Color: Beige, Size: 4
This is a really nice linen suit! The jacket is beautifully made and well-tailored, with a fun speckled texture that has lots of pretty color variation (we ordered the beige). When I placed it side by side with a similar linen suit from another brand, the difference in the linen texture was really noticeable — this had a much stronger linen character that stands out! It has three useful pockets on the outside of the jacket, which is great for little hands. The only downside is that one of the inside pockets is just for show (faux), which was a bit surprising and somewhat disappointing for my little guy. The pants have pockets too, but they aren’t very deep — perfect for small treasures, but not much more. The pants are made from a lighter, thinner single-layer linen compared to the fully lined, double-layer jacket, which makes sense for comfort and easy movement. The pants didn’t come with a front crease ironed in, so you’ll want to press one yourself. The linen did pick up some creases from being folded in the package, but it doesn’t seem quite as wrinkly as some other linen fabrics I’ve tried. Still, like most linen clothes, especially for boys, the pants will need occasional ironing to keep them looking neat and crisp, especially after a day of play and general wear. The structured, lined jacket stays looking smoother and more put-together with less effort. It also came with a bow tie, a neck tie, and a tuxedo-style white shirt as extras. The ties aren’t great quality — they’d work fine for quick photos but probably won’t hold up to much actual wear. The formal white shirt feels a bit funny paired with the casual linen suit, but I don’t mind at all. We already have white shirts that we prefer, so we’ll use those instead. For us, the extras are really just bonus items we won’t plan on using. Overall, it’s a handsome little suit that’s perfect for special occasions like weddings, family photos, or holiday events. My kid looked adorable in it! The stronger linen texture on the jacket gives it a premium feel that I really like. Just be ready for a bit of extra care with the pants to keep everything sharp.
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Reviewed in the United States on April 8, 2026
C
chzgr8er
Belleville, US
★★★★★ 5
Great suit set
Color: Light Grey, Size: 4
It is incredibly attractive and includes everything a young child needs for a special occasion. The material is a 75% polyester and 25% linen blend, and the outer fabric feels remarkably smooth. Its unstructured design allows for an attractive, natural drape, and the blend conveniently allows for machine washing at home. As is typical with linen-based materials, the fabric can be naturally stiff and prone to wrinkling, so I recommend ironing or steaming it before use. The lightweight feel makes it an excellent choice for the spring, summer, and fall months. Overall, this suit offers exceptional value for the price.
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Reviewed in the United States on April 12, 2026
A
Verified Purchase
Amazon Customer
Bozeman, US
★★★★★ 5
Summer wedding kids suit
Color: Navy, Size: 10 Years, Color: Navy, Size: 10 Years
Bought this suit for my son in the 10 youth size and honestly was pleasantly surprised by the quality for the price. The navy color looks sharp and dressy without being too stiff or uncomfortable. The material has a little stretch, which helped it fit nicely and made it comfortable for him to move around in. The adjustable waist was a huge plus, especially for growing kids. It fit true to size overall, though the blazer sleeves were slightly long on my son. The pants had a nice slim look without being too tight. We paired it with white sneakers for a more modern look and it came out adorable. This would be perfect for weddings, graduations, concerts, communion, school events, or family photos. Overall, very happy with the purchase and would definitely buy again.
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Reviewed in the United States on May 18, 2026

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